This Week in Pediatric Oncology #96
GPC2 Directed Immunotherapy for GPC2 Expressing Solid Tumors with Dr. Kristopher Bosse
April 12, 2022 — Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Kristopher Bosse: an attending physician in the Division of Oncology at Children's Hospital of Philadelphia (CHOP). Dr. Bosse discusses his latest project that focuses on GPC2 Directed Immunotherapy, including what makes it a better target, the benefits & challenges of selecting new targets, as well as the strategy & applicability of the immunotherapy on solid tumors.
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/CEvlSC8dHeQ
This Week in Pediatric Oncology #95
Patient Advocates' Views in Neuroblastoma with Nick Bird & Donna Ludwinski
March 11, 2022 — Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined Solving Kids’ Cancer’s patient advocates, Nick Bird & Donna Ludwinski. Nick & Donna, along with other patient advocates, recently published a groundbreaking report, “When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma“. Listen in as they discuss the importance of advocacy and being the voice of cancer patients and their families, and how all stakeholders (i.e. academia, advocates, and big pharma) can collaborate and advance treatment options for pediatric cancer patients.
You can read their full paper here: https://ascopubs.org/doi/full/10.1200/JCO.21.01916?bid=123546590&cid=DM9111
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/rFd4Fwa_XVg
This Week in Pediatric Oncology #94
Improved Outcome in Pediatric High-Risk Neuroblastoma with Dr. Wayne Furman
February 16, 2022 — In this episode, our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined by Dr. Wayne Furman. Dr. Furman recently retired from the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Prior to his retirement, Dr. Furman had a paper published in the Journal of Clinical Oncology on his Phase II trial using hu14.18K322A in newly diagnosed high-risk neuroblastoma pediatric patients. Listen in as he discusses the results of this trial & the future of neuroblastoma treatments.
You can read his full paper here: https://ascopubs.org/doi/abs/10.1200/JCO.21.01375?journalCode=jco
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Uf9UOGW3y-Q
This Week in Pediatric Oncology #93
CureWorks & Caring Cross: Pathways to Advance Cell & Gene Therapy with Dr. Rimas Orentas
January 20, 2022 — Tune in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Rimas Orentas - the Scientific Director of Caring Cross & a Professor from Seattle Children's Hospital. In this episode, Dr. Orentas discusses his expertise in cellular gene therapy - the accessibility, production, testing, and the importance of diversity and inclusion amongst research subjects.
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/AFmMxBeZOa4
This Week in Pediatric Oncology #92
mRNA - Not just for COVID - What is its Application in Pediatric Cancer? with Dr. Elias Sayour
January 6, 2022 — Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, meet with Dr. Elias Sayour from the University of Florida. While many are familiar with mRNA due to its COVID-19 vaccine application, Dr. Sayour discusses mRNA within the pediatric brain tumor landscape - including preclinical work, its delivery & distribution, as well as promising future opportunities for pediatric cancer patients.
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/uk1dxJe3VoY
This Week in Pediatric Oncology #91
What Breakthroughs are on the Horizon for DIPG? with Dr. Mariella Filbin
December 2, 2021 — Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel are joined by Dr. Mariella Filbin from Dana-Farber Cancer Institute/Boston Children's Hospital. Dr. Filbin discusses her expertise within DIPG including transcriptomics and epigenomics, as well as what is on the horizon for research - both challenging and exciting advances.
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/7NAibEpTA0w
This Week in Pediatric Oncology #90
Newborn Screening For Predisposition to Pediatric Cancers with Dr. Lisa Diller
November 4, 2021 — Listen in as our hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Lisa Diller from Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dr. Diller discusses the possibilities of genetic testing for pediatric cancer predisposition syndromes in newborn screening programs, but with uncertain benefits and costs. She recently authored a paper exploring the mathematical modeling of a screening program for cost and benefit.
You can read her full paper here: https://pubmed.ncbi.nlm.nih.gov/33767345/
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/Fd1flMgbfLw
This Week in Pediatric Oncology #89
Spotlight on Immunotherapy for Pediatrics: Natural Killer T-Cells with Dr. Andras Heczey
August 30, 2021 — Hosts, Dr. Timothy Cripe and Dr. Brenda Weigel, are joined in this episode by Dr. Andras Heczey from Texas Children's Hospital/Baylor College of Medicine. Listen in as they discuss Dr. Heczey's expertise & research in utilizing Natural Killer (NK) T-cells for pediatric immunotherapy treatment and the process of doing so.
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=nJZYz1XrsyY
This Week in Pediatric Oncology #88
The ACCELERATE ALKi Pediatric Strategy Forum with Prof. Andy Pearson & Prof. Louis Chesler
July 29, 2021 — Hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, meet with Prof. Andy Pearson and Prof. Lou Chesler to discuss ACCELERATE forums. Prof. Pearson & Prof. Chesler played pivotal roles in the start of the ALKi ACCELERATE forum. Listen in as they discuss their experiences from the very first meeting, how topics are chosen, and the importance of bringing together key people from different industries.
To learn more about ACCELERATE, go to: https://www.accelerate-platform.org/
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/zZiE19fhzQQ
This Week in Pediatric Oncology #87
Biotech Solutions for Pediatric Cancer Drug Development with Dr. Samuel Blackman
June 28, 2021 — Hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Samuel Blackman to discuss biotech solutions for pediatric cancer drug development. Dr. Blackman is the Co-Founder and Chief Medical Officer of Day One Biopharmaceuticals located in South San Francisco, CA. Tune in as Dr. Blackman discusses his career journey, the origins of Day One, and the challenges in pediatric cancer drug development today.
To learn more about Day One Biopharmaceuticals, go to : https://dayonebio.com
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/PbNS-yFDTzA
This Week in Pediatric Oncology #86
Oncolytic Virotherapy in Pediatric Brain Tumors with Dr. Gregory Friedman
May 28, 2021 — As Brain Tumor Awareness Month draws to a close, we bring you a new TWIPO episode on the subject. Hosts, Dr. Timothy Cripe & Dr. Brenda Weigel, are joined by Dr. Gregory Friedman from the University of Alabama in Birmingham to discuss his recently published paper "Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas." Listen in as Dr. Friedman discusses the findings of this phase 1 clinical trial and the progress of oncolytic virotherapy in pediatric brain tumors.
You can access the abstract to Dr. Friedman's paper here: https://pubmed.ncbi.nlm.nih.gov/33838625/
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/OSftR6JhEtY
This Week in Pediatric Oncology #85
Brain Tumors & The Blood-Brain Barrier with Dr. Stergios Zacharoulis
May 14, 2021 — In recognition of Brain Tumor Awareness Month, TWIPO hosts Dr. Timothy Cripe and Dr. Brenda Weigel are joined by Dr. Stergios Zacharoulis of Columbia University Irving Medical Center (CUIMC), where he initiated a novel drug delivery program for pediatric brain tumors. Listen in as Dr. Zacharoulis discusses different delivery methodologies being explored and developed that bypass the blood-brain barrier.
WATCH THE VIDEO WEBCAST HERE: https://youtu.be/TEFcsd5lt1A
This Week in Pediatric Oncology #84
An Introduction to ACCELERATE with Dr. Gilles Vassal & Patricia Blanc
March 12, 2021 — Hosts Dr. Tim Cripe and Dr. Brenda Weigel met with Dr. Gilles Vassal and Patricia Blanc on the ACCELERATE Platform: Innovation for Children and Adolescents with Cancer. Dr. Gilles Vassal is the head of Clinical Research at Institut Gustave Roussy in Villejuif, France & he is also the Chair for the ACCELERATE Steering Committee. Patricia Blanc is the President & Founder of the Imagine for Margo Foundation and serves as a Patient Advocate for ACCELERATE. Listen in to hear how the ACCELERATE platform came to be & the advances they are making within the childhood cancer research landscape.
The ACCELERATE international platform provides a transparent forum to discuss and address, in a timely fashion, overarching issues in the development of innovative anticancer medicines for children and adolescents with cancer. To learn more about ACCELERATE, please visit: https://www.accelerate-platform.org/
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=R_GyqL36_dg
This Week in Pediatric Oncology #83
Dr. Christopher Dandoy on transplant-associated thrombotic microangiopathy (TA-TMA)
January 29, 2021 — Hosts Tim Cripe and Brenda Weigel welcome Dr. Chris Dandoy and parent advocate, Sarah Moore, to discuss the current research on TA-TMA and the implications for children undergoing stem cell transplant (SCT) for pediatric cancers, notably tandem SCTs for high-risk neuroblastoma. Dr. Dandoy is Assistant Professor of Clinical Pediatrics in Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children’s Hospital Medical Center and this episode discussion focused on four recently published papers by Dr. Dandoy describing effects, incidence, risk factors, screening, and treatment of this serious complication of transplants. Sarah Moore also shared her perspective as a mother to a child who recently underwent tandem SCT for high-risk neuroblastoma and has been active in parent forums discussing the incidence and implications of TA-TMA and sharing evidence-based information.
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=io13HbVwtbI
This Week in Pediatric Oncology #82
Dr. Brenda Weigel on The RACE Act & Early Phase Clinical Trials
December 8, 2020 — Host Tim Cripe welcomes his new Co-Host, Dr. Brenda Weigel, to reflect on her career, leadership, and focus areas since her last interview on TWiPO in 2017. Dr. Weigel is the Director of the Division of Pediatric Hematology/Oncology at the University of Minnesota's Cancer Center, Chair of Developmental Therapeutics in the COG, and Chair of the Pediatric Early Phase Clinical Trials Network (PEP-CTN) for the NCI.She is at the epi-center for getting new drugs into the clinic for children with cancer and shares her perspective on the impact of the game-changing RACE Act that was implemented in 2020. She weighs in on prioritization of same-class drugs, evolving clinical trial design for small patient populations, and the increasing need for international collaboration in conducting clinical trials. She also discusses the importance of quality-of-life assessments and patient-reported outcomes and shares the efforts ongoing in the US and EU regulatory landscape to advance drug development for children with cancer.
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=ANmLBfdVJYQ
This Week in Pediatric Oncology #81
Discussing Brain Tumor Research with Dr. Michael Taylor & Dr. Nabil Ahmed
October 30, 2020 — This week was International Brain Tumor Awareness Week & we're closing out the week with this engaging discussion. TWIPO Host, Dr. Timothy Cripe, met with Dr. Michael Taylor, from SickKids in Toronto, Canada, and Dr. Nabil Ahmed, from Texas Children's Hospital, to discuss their recently published paper on a novel immunotherapy approach for children with metastatic medulloblastoma and ependymoma.
You can read their full paper here: https://pubmed.ncbi.nlm.nih.gov/32341580/
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=TwBmCwq3gJc&t=1s
This Week in Pediatric Oncology #80
A Discussion with the New Chair of the Children's Oncology Group (COG), Douglas Hawkins, MD
September 30, 2020 — In honor of Childhood Cancer Awareness Month, TWIPO announces its official relaunch. Join our host, Timothy Cripe, MD, as he meets with the new Chair of the Children's Oncology Group (COG), Douglas Hawkins, MD, to discuss the future of the pediatric cancer research landscape.
WATCH THE VIDEO WEBCAST HERE: https://www.youtube.com/watch?v=p7rMXwAu3qA
This Week in Pediatric Oncology - COVID-19
The Pandemic's Impact on the Pediatric Cancer Research Landscape
April 28, 2020 — Join us in this special episode for cancer families where leaders from COG, the NCI, and the pharmaceutical industry lead a community discussion about the pandemic's impact on all aspects of pediatric cancer research including clinical trials and standard cancer care services, followed by Q&A with questions from families and attendees.
This Week in Pediatric Oncology - COVID-19
The Latest COVID-19 Insights from Doctors + Stories from the Frontline to inform Childhood Cancer Families & the General Community
March 31, 2020 — Experts from the medical community update us on our progress to-date and what to expect in the coming weeks and months. Also, parents from a New York family both diagnosed with COVID-19 will share their family’s current story/experience and important insights from the frontline.
This Week in Pediatric Oncology - COVID-19
Discussion on Impact of COVID-19 in the Pediatric Cancer Community
March 24, 2020 — As our world faces the Novel Coronavirus pandemic, it’s vital that we address key topics important to children & families in the Pediatric Cancer Community. Please listen to this informative webinar to hear from experts, ask questions, and share information on: An overview of COVID-19 pandemic: Fact versus fiction, What are the risks to immunocompromised patients?, Impact of COVID-19 on care and clinical research
Meet our Hosts
Timothy P. Cripe, MD, PhD
A principal investigator in the Center for Childhood Cancer and Blood Diseases in The Research Institute and chief of the Division of Hematology/Oncology and Bone Marrow Transplantation at Nationwide Children’s Hospital. His lab’s current research focuses on developing and testing new, targeted therapies for pediatric solid tumors and translating those findings into clinical studies. Dr. Cripe and his team investigate the use of viruses that selectively infect and kill cancer cells, study their utility for killing cancer stem cells, and were among the first in the country to launch clinical trials of attenuated viruses in children.
Brenda Weigel, MD, MSc
Dr. Brenda Weigel is currently the Director of the Division of Pediatric Hematology/Oncology. She is a professor cross-appointed at the University of Minnesota's Cancer Center and the Department of Pediatrics, and the recipient of the Lehman/Children’s Cancer Research Fund Endowed Chair in Pediatric Cancer. She is also the Co-Director of the Sarcoma Program for the Masonic Cancer Center, and an Associate Director of the Cancer Experimental Therapeutics Initiative for the Masonic Cancer Center.
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