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phase 1

clinical trial

Can a drug for another disease be used against neuroblastoma?

Study Title: Nifurtimox for Relapsed or Refractory Neuroblastoma
Researcher: Giselle Sholler, MD
Institution: University of Vermont/ Vermont Cancer Center
Study Type: Phase I clinical trial
Status: Completed

Drugs used for another disease are occasionally found to work against cancer, and sometimes this discovery happens accidently.  This was the case with Nifurtimox, a drug used to treat a parasitic disease called Chagas Disease. One of the co-founders of Solving Kids’ Cancer read a case study reporting how Nifurtimox was used for a child who contracted Chagas Disease from a blood transfusion and that the drug treatment showed a dramatic reduction in the child’s chemo-resistant neuroblastoma. Solving Kids’ Cancer quickly brought researchers together and created a clinical trial with Nifurtimox for children with neuroblastoma. This phase I clinical trial led to the development of a large multi-center phase II trial, which is ongoing.

To learn more about this trial, visit clinicaltrials.gov.

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