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phase 1

clinical trial

Can a drug for another disease be used against neuroblastoma?

Study Title: Nifurtimox for Relapsed or Refractory Neuroblastoma
Researcher: Giselle Sholler, MD
Institution: University of Vermont/ Vermont Cancer Center
Study Type: Phase I clinical trial
Status: Completed

Drugs used for another disease are occasionally found to work against cancer, and sometimes this discovery happens by accident.  This was the case with Nifurtimox, a drug used to treat a parasitic disease. One of the co-founders of Solving Kids’ Cancer read a case study reporting how Nifurtimox was used for a child who contacted Chagas Disease from a blood transfusion and also had chemo-resistant neuroblastoma and had a dramatic reduction of their tumor.  reduced the tumor size in a child with neuroblastoma that did not respond to chemotherapy. Solving Kids’ Cancer quickly brought researchers together and created a clinical trial with Nifurtimox for children with neuroblastoma. This phase I clinical trial led to the development of a large multi-center phase II trial, which is ongoing.

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