TWiPO #5 ~ Hedgehog Signaling and Itraconazole

May 19, 2011

Dr. Tim Cripe and Dr. Maureen O`Brien discuss the role of targeting of hedgehog signaling in diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other uses — such as itraconazole, an anti-fungal drug found to suppress hedgehog signaling — as a possible treatment for medulloblastoma.

1:20 feedback and comments on previous TWiPO episode

2:58 Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma; (fulltext) Proc Natl Acad Sci USA. 2011 March 15; 108(11): 4453–4458

9:22 Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13;17(4):388-99.

Please send questions and comments to TWiPO@solvingkidscancer.org

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