Neuroblastoma

Will an Antibody Recognizing a New Target in Neuroblastoma Kill Tumor Cells?

In the lab, an antibody targeting ALK expression kills neuroblastoma cells. Researchers believe that an anti-ALK antibody that targets the surface antigen will alert the immune system to attack the cancer, reducing the risk of a future recurrence. This research…

Can Engineered T-Cells Be Improved to Better Recognize and Attack Neuroblastoma Cells?

T-cell therapy has seen much success in leukemia patients. Researchers now are trying to find out if T-cell therapy using the GD2 tumor antigen, which is on the surface of the neuroblastoma cancer cells, can bring about remission in solid…

Will Combining NK Cells From a Parent With a Humanized Antibody Be More Effective in Treating Neuroblastoma?

Solving Kids’ Cancer supported this trial because researchers use a humanized monoclonal antibody known as hu14.18-IL2, which specifically targets neuroblastoma tumor cells and binds to them. The humanized monoclonal antibody may be more effective at activating the NK cells for…

Can T-Cells Be Engineered to Attack More Types of Pediatric Solid Tumors?

Researchers optimized the activity of a CAR (chimeric antigen receptor) constructed that targets GD2, an antigen on the surface of neuroblastoma to modify T cells for use in a future clinical trial. Project Title: Adoptive Cell Therapy for Adolescent/Pediatric Solid…

Can We Improve the Potency and Persistence of a Child’s T-Cells to Recognize and Kill Neuroblastoma Cells?

Solving Kids’ Cancer supported this work to develop a new and improved type of GD2-CAR T cells, and this work has advanced to a Phase I clinical trial also supported by Solving Kids’ Cancer. Project Title: Improving GD2 T-cell Immunotherapy…

Can We Train a Child’s Immune Cells to Recognize and Kill Cancer Cells?

Solving Kids’ Cancer supported this vaccine clinical trial that uses the cancer drug decitabine to help the immune cells better recognize and kill the cancer cells. Project Title: Combining Decitabine and Vaccine Therapy for Patients with Relapsed Neuroblastoma and Sarcoma…

Can We Kill Cancer Cells Using a New Drug That Stops DNA Repair?

Solving Kids’ Cancer created this research project to test CHK1 inhibitors in neuroblastoma and medulloblastoma. After this research was complete, a phase I clinical trial for children with the best approach was planned and is now underway. Project Title: CHK1…

What Drugs Will Target Cancer Stem Cells?

Solving Kids’ Cancer created this program to identify new promising agents for these kids. Researchers were able to successfully isolate populations of neuroblastoma cells with the properties of cancer stem cells Project Title: Drug Development Program for Neuroblastoma Stem Cells…

By Engineering a Herpes Virus, Can We Target Tumor Cells?

HSV1716 (Seprehvir) is a “first in class” engineered oncolytic virus derived from the herpes simplex virus, and is designed to target and destroy cancer cells. Solving Kids’ Cancer brought this cutting-edge research to the U.S. and developed the first clinical…