All Projects
Can T-Cells Be Engineered to Attack More Types of Pediatric Solid Tumors?
Researchers optimized the activity of a CAR (chimeric antigen receptor) constructed that targets GD2, an antigen on the surface of neuroblastoma to modify T cells for use in a future clinical trial. Project Title: Adoptive Cell Therapy for Adolescent/Pediatric Solid…
Can We Improve the Potency and Persistence of a Child’s T-Cells to Recognize and Kill Neuroblastoma Cells?
Solving Kids’ Cancer supported this work to develop a new and improved type of GD2-CAR T cells, and this work has advanced to a Phase I clinical trial also supported by Solving Kids’ Cancer. Project Title: Improving GD2 T-cell Immunotherapy…
Will a Vaccine Made of Stem Cells Be Effective Against a Deadly Brain Tumor in Children?
Solving Kids’ Cancer identified a novel trial using a cancer vaccine modeled after one used in adults for a deadly brain tumor called glioblastoma. As part of this trial, the vaccine will be combined with the drug imiquimod, which enhances…
Can We Train a Child’s Immune Cells to Recognize and Kill Cancer Cells?
Solving Kids’ Cancer supported this vaccine clinical trial that uses the cancer drug decitabine to help the immune cells better recognize and kill the cancer cells. Project Title: Combining Decitabine and Vaccine Therapy for Patients with Relapsed Neuroblastoma and Sarcoma…
Will Targeted Radiation Stop a Deadly Brain Tumor?
Solving Kids’ Cancer supported this project because better methods to deliver treatments to the brain stem are urgently needed. In this research study, children with DIPG are treated with an antibody connected to a radioactive isotope and delivered directly to…
Can We Kill Cancer Cells Using a New Drug That Stops DNA Repair?
Solving Kids’ Cancer created this research project to test CHK1 inhibitors in neuroblastoma and medulloblastoma. After this research was complete, a phase I clinical trial for children with the best approach was planned and is now underway. Project Title: CHK1…
What Drugs Will Target Cancer Stem Cells?
Solving Kids’ Cancer created this program to identify new promising agents for these kids. Researchers were able to successfully isolate populations of neuroblastoma cells with the properties of cancer stem cells Project Title: Drug Development Program for Neuroblastoma Stem Cells…
By Engineering a Herpes Virus, Can We Target Tumor Cells?
HSV1716 (Seprehvir) is a “first in class” engineered oncolytic virus derived from the herpes simplex virus, and is designed to target and destroy cancer cells. Solving Kids’ Cancer brought this cutting-edge research to the U.S. and developed the first clinical…
Vinblastine and Sirolimus in Patients With Recurrent or Refractory Solid Tumors Including CNS Tumors
Solving Kids’ Cancer initiated a research project to screen thousands of drugs that were not used for cancer against neuroblastoma tumor-initiating stem cells. These cells are a special subset of tumor cells that may be responsible for relapse in patients.…