All Projects

Which Virus is Most Effective at Killing Cancer Cells?

Solving Kids’ Cancer developed a novel program to harness cutting-edge technology to identify more promising viruses. Project Title: Oncolytic Virus Development Program for Neuroblastoma Researcher: David Stojdl, PhD Institution: Children’s Hospital of Eastern Ontario Research Institute Study Type: Preclinical Status:…

Can a Transplant Using a Parent’s Stem Cells Followed by a Parent’s NK Cells Help Fight Cancer in a Child?

Haploidentical transplant, which uses donor bone marrow from a half-matched parent or sibling, has been successful in curing some cancers, including leukemia.  Solving Kids’ Cancer supported this clinical trial based on prior research. Project Title: Reduced Intensity Haploidentical Transplantation with…

Will a Modified Small Pox Virus Kill Cancer Cells?

Solving Kids’ Cancer initiated and funded the first trial in children using JX-594, a virus strain derived from the same vaccine used to eradicate small pox, for children with solid tumors. Project Title: Vaccinia Virus JX-594 for Relapsed/Refractory Neuroblastoma and…

By Finding Weaknesses in Cancer Stem Cells, Can We Prevent Relapse?

Researchers at the Hospital for Sick Children in Toronto were among the first to identify and characterize neuroblastoma cancer stem cells, which are believed to be responsible for relapse. Researchers isolated these unique cancer cells from patients, and screened hundreds…

Can a Drug For Another Disease Be Used Against Neuroblastoma and Brain Tumors?

After the successful completion of the phase 1 trial, which determined both the safety and correct dosage of the combination of drugs, Solving Kids’ Cancer launched a phase II trial to test Nifurtimox in more children with neuroblastoma, and also in…

Can a Drug For Another Disease Be Used Against Neuroblastoma?

Drugs used for another disease are occasionally found to work against cancer, and sometimes this discovery happens by accident. This was the case with Nifurtimox, a drug used to treat a parasitic disease. Study Title: Nifurtimox for Relapsed or Refractory…