Will a Modified Small Pox Virus Kill Cancer Cells?

Solving Kids’ Cancer initiated and funded the first trial in children using JX-594, a virus strain derived from the same vaccine used to eradicate small pox, for children with solid tumors. Project Title: Vaccinia Virus JX-594 for Relapsed/Refractory Neuroblastoma and Other Pediatric Solid Tumors Researcher: Timothy Cripe, MD, PhD Institution: Cincinnati Children’s Hospital, Texas Children’s…

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By Finding Weaknesses in Cancer Stem Cells, Can We Prevent Relapse?

Researchers at the Hospital for Sick Children in Toronto were among the first to identify and characterize neuroblastoma cancer stem cells, which are believed to be responsible for relapse. Researchers isolated these unique cancer cells from patients, and screened hundreds of drugs against them. Project Title: Neuroblastoma Drug Discovery and Development Program Researcher: David Kaplan,…

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Can a Drug For Another Disease Be Used Against Neuroblastoma and Brain Tumors?

After the successful completion of the phase 1 trial, which determined both the safety and correct dosage of the combination of drugs, Solving Kids’ Cancer launched a phase II trial to test Nifurtimox in more children with neuroblastoma, and also in children with medulloblastoma. Project Title: Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma Researcher: Giselle…

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