Neuroblastoma
Can a Transplant Using a Parent’s Stem Cells Followed by a Parent’s NK Cells Help Fight Cancer in a Child?
Haploidentical transplant, which uses donor bone marrow from a half-matched parent or sibling, has been successful in curing some cancers, including leukemia. Solving Kids’ Cancer supported this clinical trial based on prior research. Project Title: Reduced Intensity Haploidentical Transplantation with NK Cell Infusion for Pediatric Acute Leukemia and High Risk Solid Tumors Researcher: Kenneth DeSantes,…
Read MoreWill a Modified Small Pox Virus Kill Cancer Cells?
Solving Kids’ Cancer initiated and funded the first trial in children using JX-594, a virus strain derived from the same vaccine used to eradicate small pox, for children with solid tumors. Project Title: Vaccinia Virus JX-594 for Relapsed/Refractory Neuroblastoma and Other Pediatric Solid Tumors Researcher: Timothy Cripe, MD, PhD Institution: Cincinnati Children’s Hospital, Texas Children’s…
Read MoreBy Finding Weaknesses in Cancer Stem Cells, Can We Prevent Relapse?
Researchers at the Hospital for Sick Children in Toronto were among the first to identify and characterize neuroblastoma cancer stem cells, which are believed to be responsible for relapse. Researchers isolated these unique cancer cells from patients, and screened hundreds of drugs against them. Project Title: Neuroblastoma Drug Discovery and Development Program Researcher: David Kaplan,…
Read MoreCan a Drug For Another Disease Be Used Against Neuroblastoma and Brain Tumors?
After the successful completion of the phase 1 trial, which determined both the safety and correct dosage of the combination of drugs, Solving Kids’ Cancer launched a phase II trial to test Nifurtimox in more children with neuroblastoma, and also in children with medulloblastoma. Project Title: Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma Researcher: Giselle…
Read MoreCan a Drug For Another Disease Be Used Against Neuroblastoma?
Drugs used for another disease are occasionally found to work against cancer, and sometimes this discovery happens by accident. This was the case with Nifurtimox, a drug used to treat a parasitic disease. Study Title: Nifurtimox for Relapsed or Refractory Neuroblastoma Researcher: Giselle Sholler, MD Institution: University of Vermont/ Vermont Cancer Center Study Type: Phase…
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