Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?
This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and other GD2+ solid tumors. Project Title: Activated T-Cells Armed With GD2 Bispecific Antibody in Children and Young Adults With Neuroblastoma and Osteosarcomas Researcher: Maxim Yankelevich,…Read More
Can We Train a Child’s Immune Cells to Recognize and Kill Cancer Cells?
Solving Kids’ Cancer supported this vaccine clinical trial that uses the cancer drug decitabine to help the immune cells better recognize and kill the cancer cells. Project Title: Combining Decitabine and Vaccine Therapy for Patients with Relapsed Neuroblastoma and Sarcoma Researcher: Kenneth Lucas, MD Institutions: University of Louisville Study Type: Phase I clinical trial Status:…Read More
By Engineering a Herpes Virus, Can We Target Tumor Cells?
HSV1716 (Seprehvir) is a “first in class” engineered oncolytic virus derived from the herpes simplex virus, and is designed to target and destroy cancer cells. Solving Kids’ Cancer brought this cutting-edge research to the U.S. and developed the first clinical trial for children in 2010. Project Title: Dose Escalation Study of Intratumoral Herpes Simplex Virus-1…Read More
Vinblastine and Sirolimus in Patients With Recurrent or Refractory Solid Tumors Including CNS Tumors
Solving Kids’ Cancer initiated a research project to screen thousands of drugs that were not used for cancer against neuroblastoma tumor-initiating stem cells. These cells are a special subset of tumor cells that may be responsible for relapse in patients. Project Title: Vinblastine and Sirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors Including…Read More
Can a Transplant Using a Parent’s Stem Cells Followed by a Parent’s NK Cells Help Fight Cancer in a Child?
Haploidentical transplant, which uses donor bone marrow from a half-matched parent or sibling, has been successful in curing some cancers, including leukemia. Solving Kids’ Cancer supported this clinical trial based on prior research. Project Title: Reduced Intensity Haploidentical Transplantation with NK Cell Infusion for Pediatric Acute Leukemia and High Risk Solid Tumors Researcher: Kenneth DeSantes,…Read More
Will a Modified Small Pox Virus Kill Cancer Cells?
Solving Kids’ Cancer initiated and funded the first trial in children using JX-594, a virus strain derived from the same vaccine used to eradicate small pox, for children with solid tumors. Project Title: Vaccinia Virus JX-594 for Relapsed/Refractory Neuroblastoma and Other Pediatric Solid Tumors Researcher: Timothy Cripe, MD, PhD Institution: Cincinnati Children’s Hospital, Texas Children’s…Read More