Can Nivolumab Treat Childhood Brain Tumors?

Project Title: Anti-PD1 Nivolumab in Children With Brain Tumors
Researcher: Ira Dunkel, MD
Institution: Memorial Sloan-Kettering Cancer Center; Johns Hopkins University Hospital
Study Type: Phase 1 Clinical Trial
Status: Opening in 2018

Recent results from clinical trials in adults with various tumor types have shown exciting and promising results. Nivolumab has not yet been studied in any children with brain tumors. This phase I trial will study the safety of nivolumab in children with recurrent brain tumors and then perform another phase I study of the combination of ipilimumab and nivolumab. This trial is the first time this exciting immunotherapy approach is being used in children with brain tumors.

Charity Partners: A Kid’s Brain Tumor Cure Foundation, Ty Louis Campbell Foundation