A Welcome Gift for the Pediatric Brain Tumor Community

What began as a proposal for a four-center US-based clinical trial of promising combination therapy for children battling brain tumors, has expanded into a large-scale clinical trial at 58 centers in 13 countries, that brings new hope to children across the globe.

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Brain Tumor Clinical Trial Now Enrolling Children

A Phase 1 clinical trial leveraging the re-engineered poliovirus is now open for enrollment to children 12 years and older at the Preston Robert Tisch Brain Tumor Center, Duke University Medical Center. After years of following the progress of this promising therapy against adult glioblastoma and working with the research team on behalf of children, Solving Kids’ Cancer teamed up with The Andrew McDonough B+ Foundation to help move this forward in a trial for pediatric brain tumor patients.

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Targeted Therapy for Children with ALK-Driven Neuroblastoma

Lorlatinib, an investigational drug candidate currently in late-stage clinical development for the treatment of lung cancer may also prove effective for the treatment of the pediatric cancer neuroblastoma. Solving Kids’ Cancer is leading an international effort of like-minded nonprofits to provide nearly $400,000 of collaborative funding for an innovative clinical trial to bring a potentially life-saving therapy to kids.

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Advocacy in Action

Solving Kids’ Cancer was the first charity to ever go against the UK healthcare system without a pharmaceutical company involved. As a result, the National Institute for Health and Care Excellence (NICE) recently announced that it has upheld SKC’s appeal against the Institute’s decision not to recommend dinutuximab for treating high-risk neuroblastoma. 

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Precision Medicine Advances for Children With Neuroblastoma

Solving Kids’ Cancer (SKC) together with Wade’s Army announce their joint financial support of this Phase 1 clinical trial to test the safety and efficacy of various investigational drugs that will leverage precision medicine for children with neuroblastoma. This Next Generation Personalized Neuroblastoma Therapy – also known as NEPENTHE (Greek for “medicine for sorrow”) – is the first precision medicine trial for children that will robustly analyze the genomics of their cancer and use combinations of investigational drugs to target specific mutations in their tumors.

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SKC Formally Appeals NICE Decision

The National Institute for Health and Care Excellence (NICE) heard an appeal led by Solving Kids’ Cancer (SKC) against its recent decision to deny children in the UK treatment that is proven to significantly increase the chance of survival for children diagnosed with an aggressive childhood cancer, neuroblastoma.

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Access to Cures Should Have No Borders

The British healthcare system has rejected an FDA/EMA-approved treatment proven to increase survival rates for children with cancer.  NICE (National Institute for Health and Care Excellence) has rejected access to the drug across the UK, stating cost as the reason.  However, when analyzing the real expense on taxpayers, the cost amounts to less than 3 pence per person, per year, in order to give these children access to the life-saving antibody.

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