This Week in Pediatric Oncology - Episode #31
Secondary Cancers in Childhood Cancer Survivors
October 3, 2013 — Dr. Joseph Neglia (University of Minnesota) is nationally and internationally recognized for his contributions to the field of childhood cancer long-term effects. He is the featured guest in this week's podcast episode, and answers questions from host Dr. Tim Cripe (Nationwide Children’s Hospital), and co-hosts Dr. Robyn Dennis (Nationwide Children’s Hospital), Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids’ Cancer), about late effects and the risk of secondary cancers among childhood cancer survivors.
This Week in Pediatric Oncology - Episode #30
A Discussion on the Cancer Risk in Families
September 19, 2013 — Recently, several published papers have discussed the risk of cancer among family members of children with cancer. TWIPO host Dr. Timothy Cripe and fellow co-host Dr. Robyn Dennis (Nationwide Children's) break down the topic of familial cancer risk with certified genetic counselor Elizabeth Varga (Nationwide Children's) and Donna Ludwinski (Solving Kids' Cancer) and what families should take away from these studies.
This Week in Pediatric Oncology - Episode #29
Understanding the Circuitry Behind Pediatric Solid Tumors
September 5, 2013 — New revelations in DNA damage and cell repair mechanisms in childhood cancer may help scientists identify the underlying cause of pediatric solid tumors and lead to the development of new therapies. Dr. Peter Houghton (Nationwide Children's) speaks with TWIPO host Dr. Timothy Cripe and fellow co-hosts Dr. Lionel Chow (Cincinatti Children's) and Dr. Robyn Dennis (Nationwide Children's) about his recent paper published in the Proceedings of the National Academy of Sciences on the mTOR pathway and role of ATM.
This Week in Pediatric Oncology - Episode #28
Uniting the Childhood Cancer Community
August 15, 2013 — TWIPO host Dr. Tim Cripe (Nationwide Children's) and co-hosts speak with Vickie Buenger from Texas A&M University about her role as a childhood cancer advocate. A founding member of the Coalition Against Childhood Cancer, Buenger discusses the organization's principles and future projects to bring the childhood cancer community together.
This Week in Pediatric Oncology - Episode #27
Advocating for Better Research for our Kids
August 1, 2013 — Host Dr. Tim Cripe (Nationwide Children's) and co-host Dr. Jeffrey Auletta (Nationwide Children's) interview Solving Kids' Cancer co-founder and Executive Director Scott Kennedy and co-director of research programs Donna Ludwinski. Both Scott and Donna share their personal stories that led them to Solving Kids' Cancer and their shared passion to improve survival for children with the deadliest childhood cancers through research advocacy.
This Week in Pediatric Oncology - Episode #26
Killer Immunoglobulin Receptor (KIR) Mismatch in Neuroblastoma
May 7, 2012 — Host Dr. Tim Cripe (Nationwide Children's) and co-hosts Dr. Lionel Chow (Cincinnati Children's), Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids' Cancer) quiz Dr Paul Sondel and Dr. Ken DeSantes (both from University of Wisconsin - Madison) on NK cells and the implications of KIR/KIR-ligand mismatch (killer immunoglobulin-like receptor) with regard to immunotherapy treatment of neuroblastoma.
This Week in Pediatric Oncology - Episode #25
A Discussion on Histones in Pediatric Gliomas
April 5, 2012 — Host Dr. Tim Cripe welcomes back co-host Dr. Lionel Chow to discuss somatic mutations in pediatric brain tumors. After recapping the consensus paper on molecular subgroups in medulloblastoma, Dr. Chow highlights the significance of the driver mutations in histone H3.3 in pediatric glioblastoma. Results of whole-exome sequencing have shown that significantly more somatic mutations are present in adult tumors compared to pediatric tumors. This difference might suggest a reason for better success rates in pediatric tumors and possibly more escape mechanisms in adult tumors.
This Week in Pediatric Oncology - Episode #24
Cord Blood Banking: Interview with Machi Scaradavou
March 6, 2012 — Dr. Tim Cripe welcomes Dr. Andy Kolb from AI DuPont in this episode of TWiPO, and special guest Dr. Andromachi Scaradavou, the Medical Director of New York Blood Center's National Cord Blood Program. NYBC is the world's oldest and largest public cord blood bank, and collects, processes, tests, and stores cord blood that mothers donate shortly after birth. The cord blood is for children and adults with no related donor available who need a hematopoietic stem cell transplant for life-threatening illnesses.
This Week in Pediatric Oncology - Episode #23
Neuroblastoma Jeopardy 2011
January 26, 2012 — In 2011, there were over 1300 new articles published on neuroblastoma in the medical literature. Join Dr. Tim Cripe and his co-host Dr. Lars Wagner in a fast-paced, in-depth, and comprehensive survey of 18 of the most important papers on neuroblastoma published in 2011. Dr. Cripe and Dr. Wagner explore and discuss the compelling evidence reported on a variety of topics, including epidemiology, risk stratification, clinical trials, ALK mutation and expression, new targets, and genetics.
This Week in Pediatric Oncology - Episode #22
Brain Tumor Year-End Round Robin
December 5, 2011 — Join Dr. Tim Cripe and his co-host Dr. Lionel Chow for a fast-paced, in-depth, and comprehensive survey of 15 important recent papers on pediatric brain tumor research, addressing medulloblastoma, ependymomas, and gliomas. Dr. Cripe and Dr. Chow explore and discuss the compelling evidence reported on a variety of topics, including viral causes and therapeutic implications, biomarkers, genomics, proteomics, targets, classification, risk stratification, treatment side-effects, proton-beam radiation therapy, and results of recent clinical trials.
This Week in Pediatric Oncology - Episode #21
An Interview With Dr. Beatrice Lampkin
November 29, 2011 — Dr. Tim Cripe and co-hosts Dr. Maureen O'Brien and Dr. Raj Nagarajan interview a pediatric hematology/oncology legend, Dr. Beatrice Lampkin, who served as Director of Cincinnati Children's Division of Hematology/Oncology in the 1970s. They explore her career and her contributions to leukemia therapy and the challenges she faced as an early leader in the field as a female. She describes her experience with polio, paralysis from the neck down, crutches for mobility, and later, her confinement to a wheelchair. Revealing another era in communications with parents and patients in the 1960s and 1970s, she explains how parents were advised to use the term "anemia" to describe their child's condition rather than "leukemia" to explain why the child would require periodic blood transfusions, in order to prevent shunning by friends and family.
This Week in Pediatric Oncology - Episode #20
The F-word in Pediatric Cancer Research
November 15, 2011 — Host Dr. Tim Cripe warns: “If your blood isn’t boiling by the end, you weren't listening.” Hear Tim and co-host Dr. Lionel Chow discuss pediatric cancer research funding with guests Dr. C. Patrick Reynolds, Dr. E. Anders Kolb, and parent Joe McDonough. Dr. Pat Reynolds puts government spending on the number one disease killer of children in the US in perspective, comparing the tiny $200M spent on pediatric cancer research to the foreign aid budget of $22B (less than 1%). For example, $1.6B goes to Egypt alone. The COG budget is a mere $46M. The DOD budget is $700B. Dr. Lionel Chow mentions an enlightening fact – private donations to St Jude exceed $600M per year, on top of the givers’ paying taxes. This is 3 times the entire NCI budget for pediatric cancer research for all institutions in the US.
This Week in Pediatric Oncology - Episode #19
More on Hedgehog signaling, brain tumor risk from cell phone use, and FDA approval of cancer drugs
October 30, 2011 — Several just-published papers in the literature relate to recent podcast episodes, and host Dr. Tim Cripe and co-host Dr. Lionel Chow review these interesting developments. Hedgehog Signaling: Recent papers discussing this pathway in neuroblastoma and rhabdomyosarcoma are discussed, with implications for treatment in these tumor types with itraconozole. Cell phone and brain tumor risk: The controversy concerning criticism by the Environmental Health Trust of a study showing that cell phone use does not increase risk of brain tumors in children is explored.
This Week in Pediatric Oncology - Episode #18
Targeting EWS-FLI1 in Ewing’s Sarcoma: Interview with Dr. Jeff Toretsky
October 18, 2011 — Host Dr. Tim Cripe and co-host Dr. Lionel Chow welcome special guest Dr. Jeff Toretsky on TWiPO to discuss his clinical and research interest in Ewing's sarcoma. Dr. Toretsky explains the challenges of developing a clinical grade drug from a small molecule for a specific target such as EWS-FLI1. The small market for a disease like Ewing's creates formidable hurdles for researchers, yet Dr. Toretsky is driven on by the question "If I don't do this, who will?"
This Week in Pediatric Oncology - Episode #17
Personalized medicine: Interview with Dr. Giselle Sholler
October 13, 2011 — Host Dr. Tim Cripe and co-hosts Dr. Lars Wagner and Dr. Lionel Chow welcome guest Dr. Giselle Sholler on this episode of TWiPO. Dr. Sholler gives the background to her current research interest in neuroblastoma and describes her nifurtimox trials and how she formed the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC). The physicians also discuss the specifics of the personalized medicine feasibility trial now open for neuroblastoma.