This Week in Pediatric Oncology - Episode #16
Genetic Underpinnings of Ewing Sarcoma: Interview with Dr. Stephen L. Lessnick
October 7, 2011 — Dr. Tim Cripe and co-hosts Dr. Lionel Chow and Dr. Lars Wagner welcome special guest Dr. Stephen Lessnick for an in-depth discussion on the progress to date in understanding the genetics of Ewing's sarcoma. The challenges of interpreting the gene expression data as well as the ethics of collecting tumor specimens for research purposes are also explored.
This Week in Pediatric Oncology - Episode #15
A Discussion on MicroRNAs and hereditary cancer
September 28, 2011 — Join host, Dr. Tim Cripe, with his co-hosts Drs. Jim Geller, Lionel Chow, and Lars Wagner in a robust discussion with special guest Dr. Kathryn Wikenheiser-Brokamp on the implications of DICER1, rare tumor registries, and difficult issues surrounding genetic counseling.
This Week in Pediatric Oncology - Episode #14
An Interview with Dr. Kate Matthay
August 24, 2011 — In this enlightening interview with Dr. Kate Matthay, a renowned leader in the neuroblastoma research community, host Dr. Tim Cripe draws out the inspiration for her early interest in medicine and why her career grew with a focus on neuroblastoma. Dr. Matthay explains the history and challenges of clinical research for neuroblastoma.
This Week in Pediatric Oncology - Episode #13
Updates, epidemiology of CNS tumors, birth order, and cell phone risks
August 19, 2011 — Host Dr. Tim Cripe and co-hosts Dr. Lionel Chow and Dr. Jim Geller discuss updates to previous TWiPO episodes reporting on recent press coverage and publications of BiTE antibodies and modified T-cell approaches, and then discuss recent studies on birth defects, birth order, and cell phone use and a possible link to the risk of childhood cancers.
This Week in Pediatric Oncology - Episode #12
ALL: Anti-CD19 BiTE and Genetic Risk Groups
August 5, 2011 — Host Dr. Tim Cripe and co-host Maureen O’Brien discuss recent papers on immunotherapy and DNA sequencing studies revealing new potential targets in acute lymphoblastic leukemia (ALL).
This Week in Pediatric Oncology - Episode #11
BuMel SIOP results and MIBG transplant with Dr. Brian Weiss
July 12, 2011 — Hosts Dr. Tim Cripe and Dr. Lars Wagner discuss with guest Dr. Brian Weiss (Cincinnati Children's Hospital) the implications of the recent results comparing two chemotherapy combinations for transplant regimens in children with high-risk neuroblastoma in Europe. The BuMel (busulfan, melphalan) regimen resulted in better survival and lower toxicity than CEM (carboplatin, etoposide, melphalan), a regimen used for transplant in the COG for a decade.
This Week in Pediatric Oncology - Episode #10
An Interview with Dr. Robert Seeger
July 7, 2011 — Host Dr. Tim Cripe interviewed Dr. Robert Seeger from CHLA (Children's Hospital of Los Angeles) about his contributions to improvements in treating neuroblastoma as well as his vision for future advances. Dr. Seeger's career has been remarkable in that he began with an interest in immunotherapy and neuroblastoma as an intriguing model for this approach and has consequently been involved in every major advance in treating neuroblastoma, including the pivotal 1984 discovery of the first-oversimplification of an oncogene for any cancer – MYCN and the 1985 demonstration that MCYN could be used to predict survival.
This Week in Pediatric Oncology - Episode #9
An Interview with Dr. Peter Adamson
June 16, 2011 — Host Dr. Tim Cripe of "This Week in Pediatric Oncology" podcast interviews Dr. Peter Adamson, new Chair of the Children's Oncology Group (COG). Co-hosts for this episode are Dr. Jim Geller, Dr. Raj Nagarajan, and Dr. Lionel Chow. This conversation includes Dr. Adamson's background and interest in pediatric oncology and openly addresses the much-needed advances in drug development for pediatric tumors that are distinct from adult tumors. On the heels of the remarkable ch14.18 development story in neuroblastoma, Dr. Adamson explains the need for a "virtual" drug company that consists of a public-private partnership to develop drugs in a similar narrow venue, which is underway.
This Week in Pediatric Oncology - Episode #8
Seneca Valley Virus and Medulloblastoma
June 9, 2011 — An oncolytic virus for a common childhood brain tumor. Hosts Dr. Tim Cripe, Dr. Lars Wagner, and Dr. Lionel Chow discuss a recent publication by researchers at Baylor/Texas Children's in Houston that shows remarkable results of Seneca Valley virus SVV-001 on orthotopic mouse models of medulloblastoma. The TWiPO hosts raise many interesting points about this research and highlight the strengths as well as limitations of this work. This exciting research provides new evidence of promise for oncolytic virus therapy for childhood tumors.
This Week in Pediatric Oncology - Episode #7
Interview with E. Anders Kolb and Andrew Napper on drug development
June 2, 2011 — Host Dr. Tim Cripe interviews Dr. E. Anders Kolb and Dr. Andrew Napper from Nemours in Wilmington, Delaware. This informative discussion covers the strategies, scope, and challenges of target discovery, drug development, and preclinical testing for pediatric cancers, a complex process that has been accelerated by high throughput screening technology that has only recently become available in academic settings.
This Week in Pediatric Oncology - Episode #6
An Interview with Dr. Archie Bleyer
May 26, 2011 — Dr. Tim Cripe interviews Dr. Archie Bleyer about his career and research interest in improving survival rates in adolescents and young adults (AYA) affected by cancer. Dr. Bleyer is the Medical Director of Clinical Research at St. Charles Cancer Care in Bend, Oregon, and a Clinical Research Professor at Oregon Health & Sciences University in Portland. He also is a Professor of Pediatrics at The University of Texas Medical School at Houston and Senior Advisor of the Aflac/CureSearch Adolescent and Young Adult Cancer Research, and founding member of the LiveStrong Young Adult Alliance.
This Week in Pediatric Oncology - Episode #5
Hedgehog Signaling and Itraconazole
May 19, 2011 — Discussion of the role of hedgehog signaling and repositioning of drugs for pediatric cancers such as anti-fungal drug itraconazole. Hosts Dr. Tim Cripe and Dr. Maureen O'Brien discuss the role of targeting of hedgehog signaling in diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other uses -- designed for other uses -- such as itraconazole, an anti-fungal drug found to suppress hedgehog signaling -- as a possible treatment for medulloblastoma.
This Week in Pediatric Oncology - Episode #4
Meetings Recap and Immunotherapy for Synovial Cell Sarcoma
May 8, 2011 — Host Dr. Tim Cripe and co-host Dr. Jim Geller discuss updates after two recent meetings and then discuss an exciting paper just published on "Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1" J Clin Oncol. 2011 Mar 1;29(7):917-24. Epub 2011 Jan 31. by Paul Robbins and colleagues at the NCI.
This Week in Pediatric Oncology - Episode #3
Vincristine Pharmacogenetics, Irinotecan/Temozolomide for Relapsed Neuroblastoma
April 25, 2011 — Host Tim Cripe, MD, PhD, asks his co-hosts to discuss two recent papers that provide new information about genetic predisposition to increased toxicity to vincristine in some children, and the results of a phase II study using a combination therapy (irinotecan and temozolomide) in relapsed or refractory neuroblastoma.
This Week in Pediatric Oncology - Episode #2
An Interview with Dr. Gregory Reaman
April 13, 2011 — In this second episode of TWiPO, host Dr. Tim Cripe interviews Dr. Gregory Reaman about his career in pediatric oncology, the leadership of the COG, challenges, and expectations for the future.
This Week in Pediatric Oncology - Episode #1
Epidemiology of Childhood Cancer
April 11, 2011 — Solving Kids' Cancer is sponsoring a free podcast series for researchers, clinicians, advocates, and others focusing on pediatric cancer research, hosted by physician-scientist Dr. Timothy Cripe and colleagues at Cincinnati Children's. Podcasts will be published 2 to 4 times per month with discussions on new publications, clinical trials, interviews with thought leaders, and more. This first episode is a discussion among the pediatric oncologists about the recently published paper in Journal of Clinical Oncology "Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century"