All Projects

Can Small Molecule Agents Make a Big Difference?

This international collaboration of researchers and charities will rapidly introduce a new investigational drug to children and potentially result in significant clinical responses. Project Title: A Phase I/II study of PF-06463922, a next-generation ALK inhibitor, in children with relapsed /…

Will a Three-Pronged Approach be the Better Approach?

A promising way to further improve outcomes in this disease appears to be the development of adjuvant therapeutic strategies. This trial will treat children with high-risk neuroblastoma by combining anti-GD2 with mIBG therapy and a new antibody (Nivolumab). Project Title:…

Can the Polio Virus Stop Deadly Brain Tumors?

The virus is delivered via a catheter directly into the tumor by a method known as convection-enhanced delivery.  This clinical project fills a significant unmet need for children with high-risk brain tumors. PVSRIPO for Recurrent Malignant Glioma in Children Project…

Are Five Targets Better Than One? Using CTLs To Seek and Destroy

This immunotherapy treatment uses cytotoxic T lymphocytes (CTLs) for the first-time for children with neuroblastoma. CTLs are the killer T-cells of the immune system whose role is to seek out and destroy abnormal cells. Project Title: Phase I Clinical Trial…

Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?

This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and other GD2+ solid tumors. Project Title: Activated T-Cells Armed With…

Can Nivolumab Treat Childhood Brain Tumors?

Recent results from clinical trials in adults with various tumor types  have shown exciting results. Nivolumab has not yet been studied in any children with brain tumors. Project Title: Anti-PD1 Nivolumab in Children With Brain Tumors Researcher: Ira Dunkel, MD…

Can High Frequency Ultrasound Be Used for Bulky Tumors?

This clinical trial uses a new technology for childhood cancer called “High Intensity Focused Ultrasound guided by Magnetic Resonance.” This clinical trial will be the first time this noninvasive new technology will be tried in children with abdominal tumors that…

Can Genetic Mutations Be Specifically Targeted for Neuroblastoma?

By understanding the genetic features of a tumor, researchers are able to use specific drugs that interfere with certain cell processes that cause unrestricted growth. This is the first precision medicine trial for children that will robustly analyze the genomics…

Can a Child’s T-Cells be Engineered to Better Recognize and Kill Neuroblastoma Cells Safely?

Solving Kids’ Cancer supported the preclinical work that led to this current clinical trial using a CAR T-cell therapy approach with the goal of bringing these early successes in blood cancers to children with neuroblastoma and other solid tumors. This…