All Projects

First-in-Class Immunotherapy for Relapsed and Refractory Pediatric Brain Tumors

Project Title:  Phase 1 study of APX-005M CD40 agonist antibody in children with CNS tumor Researcher: Ira Dunkel, MD Institutions: Pediatric Brain Tumor Consortium Study Type: Phase I   This phase…

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Does Size Matter? Can a Nanoparticle Deliver Something Really Big?

Project Title: Optimizing SN38 nanoparticles to treat children with high-risk tumors Investigator:  Garrett Brodeur, MD Institution: Children’s Hospital of Philadelphia Study Type: Preclinical   Nanotechnology is a rapidly emerging field with the…

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Can The Measles Virus Help Topple Deadly Brain Tumors?

Project Title: Ph I Measles OV MV-NIS for recurrent Medullo/ATRT Investigators:  Sabine Mueller, MD, PhD, MAS Institutions:  UCSF Helen Diller Cancer Center, PNOC Consortium Study Type: Two arm Phase I clinical trial…

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Can Small Molecule Agents Make a Big Difference?

This international collaboration of researchers and charities will rapidly introduce a new investigational drug to children and potentially result in significant clinical responses. Project Title: A Phase I/II study of…

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Will a Three-Pronged Approach be the Better Approach?

A promising way to further improve outcomes in this disease appears to be the development of adjuvant therapeutic strategies. This trial will treat children with high-risk neuroblastoma by combining anti-GD2…

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Can the Polio Virus Stop Deadly Brain Tumors?

The virus is delivered via a catheter directly into the tumor by a method known as convection-enhanced delivery.  This clinical project fills a significant unmet need for children with high-risk…

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Are Five Targets Better Than One? Using CTLs To Seek and Destroy

This immunotherapy treatment uses cytotoxic T lymphocytes (CTLs) for the first-time for children with neuroblastoma. CTLs are the killer T-cells of the immune system whose role is to seek out…

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Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?

This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and…

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Can Nivolumab Treat Childhood Brain Tumors?

Recent results from clinical trials in adults with various tumor types  have shown exciting results. Nivolumab has not yet been studied in any children with brain tumors. Project Title: Anti-PD1…

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Immunotherapy

Will a Three-Pronged Approach be the Better Approach?

A promising way to further improve outcomes in this disease appears to be the development of adjuvant therapeutic strategies. This trial will treat children with high-risk neuroblastoma by combining anti-GD2…

Read More

Can the Polio Virus Stop Deadly Brain Tumors?

The virus is delivered via a catheter directly into the tumor by a method known as convection-enhanced delivery.  This clinical project fills a significant unmet need for children with high-risk…

Read More

Are Five Targets Better Than One? Using CTLs To Seek and Destroy

This immunotherapy treatment uses cytotoxic T lymphocytes (CTLs) for the first-time for children with neuroblastoma. CTLs are the killer T-cells of the immune system whose role is to seek out…

Read More

Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?

This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and…

Read More

Can Nivolumab Treat Childhood Brain Tumors?

Recent results from clinical trials in adults with various tumor types  have shown exciting results. Nivolumab has not yet been studied in any children with brain tumors. Project Title: Anti-PD1…

Read More

Can a Child’s T-Cells be Engineered to Better Recognize and Kill Neuroblastoma Cells Safely?

Solving Kids’ Cancer supported the preclinical work that led to this current clinical trial using a CAR T-cell therapy approach with the goal of bringing these early successes in blood…

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Will a New Drug That Stops Cell Repair Reduce Tumors in Children When Given With Chemotherapy?

Researchers at CHOP identified an enzyme that plays a key role in controlling the cell cycle a called checkpoint kinase or CHK1. The Wee1 inhibitor MK-1775 works with irinotecan to…

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Will an Antibody Recognizing a New Target in Neuroblastoma Kill Tumor Cells?

In the lab, an antibody targeting ALK expression kills neuroblastoma cells. Researchers believe that an anti-ALK antibody that targets the surface antigen will alert the immune system to attack the…

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Can a Vaccine Made From a Child’s Immune Cells Work Against Deadly Brain Tumors?

This new treatment targets glioma-associated antigens, which are overexpressed in ependymomas, making them ideal candidates for the immunotherapy researchers previously developed. This cutting-edge research represents the first immunotherapy trial ever…

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Neuroblastoma

Does Size Matter? Can a Nanoparticle Deliver Something Really Big?

Project Title: Optimizing SN38 nanoparticles to treat children with high-risk tumors Investigator:  Garrett Brodeur, MD Institution: Children’s Hospital of Philadelphia Study Type: Preclinical   Nanotechnology is a rapidly emerging field with the…

Read More

Can Small Molecule Agents Make a Big Difference?

This international collaboration of researchers and charities will rapidly introduce a new investigational drug to children and potentially result in significant clinical responses. Project Title: A Phase I/II study of…

Read More

Will a Three-Pronged Approach be the Better Approach?

A promising way to further improve outcomes in this disease appears to be the development of adjuvant therapeutic strategies. This trial will treat children with high-risk neuroblastoma by combining anti-GD2…

Read More

Are Five Targets Better Than One? Using CTLs To Seek and Destroy

This immunotherapy treatment uses cytotoxic T lymphocytes (CTLs) for the first-time for children with neuroblastoma. CTLs are the killer T-cells of the immune system whose role is to seek out…

Read More

Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?

This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and…

Read More

Can High Frequency Ultrasound Be Used for Bulky Tumors?

This clinical trial uses a new technology for childhood cancer called “High Intensity Focused Ultrasound guided by Magnetic Resonance.” This clinical trial will be the first time this noninvasive new…

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Can Genetic Mutations Be Specifically Targeted for Neuroblastoma?

By understanding the genetic features of a tumor, researchers are able to use specific drugs that interfere with certain cell processes that cause unrestricted growth. This is the first precision…

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Can a Child’s T-Cells be Engineered to Better Recognize and Kill Neuroblastoma Cells Safely?

Solving Kids’ Cancer supported the preclinical work that led to this current clinical trial using a CAR T-cell therapy approach with the goal of bringing these early successes in blood…

Read More

Will a New Drug That Stops Cell Repair Reduce Tumors in Children When Given With Chemotherapy?

Researchers at CHOP identified an enzyme that plays a key role in controlling the cell cycle a called checkpoint kinase or CHK1. The Wee1 inhibitor MK-1775 works with irinotecan to…

Read More

Brain Tumors

First-in-Class Immunotherapy for Relapsed and Refractory Pediatric Brain Tumors

Project Title:  Phase 1 study of APX-005M CD40 agonist antibody in children with CNS tumor Researcher: Ira Dunkel, MD Institutions: Pediatric Brain Tumor Consortium Study Type: Phase I   This phase…

Read More

Can The Measles Virus Help Topple Deadly Brain Tumors?

Project Title: Ph I Measles OV MV-NIS for recurrent Medullo/ATRT Investigators:  Sabine Mueller, MD, PhD, MAS Institutions:  UCSF Helen Diller Cancer Center, PNOC Consortium Study Type: Two arm Phase I clinical trial…

Read More

Can the Polio Virus Stop Deadly Brain Tumors?

The virus is delivered via a catheter directly into the tumor by a method known as convection-enhanced delivery.  This clinical project fills a significant unmet need for children with high-risk…

Read More

Can Nivolumab Treat Childhood Brain Tumors?

Recent results from clinical trials in adults with various tumor types  have shown exciting results. Nivolumab has not yet been studied in any children with brain tumors. Project Title: Anti-PD1…

Read More

Will a New Drug That Stops Cell Repair Reduce Tumors in Children When Given With Chemotherapy?

Researchers at CHOP identified an enzyme that plays a key role in controlling the cell cycle a called checkpoint kinase or CHK1. The Wee1 inhibitor MK-1775 works with irinotecan to…

Read More

Can Chemotherapy Be Delivered to the Brainstem in Children?

Solving Kids’ Cancer supported this new trial, which delivers chemotherapy directly into the vertebrobasilar system, because it represents a novel way to treat the disease by targeting the blood supply…

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Can a Vaccine Made From a Child’s Immune Cells Work Against Deadly Brain Tumors?

This new treatment targets glioma-associated antigens, which are overexpressed in ependymomas, making them ideal candidates for the immunotherapy researchers previously developed. This cutting-edge research represents the first immunotherapy trial ever…

Read More

Will a Vaccine Made of Stem Cells Be Effective Against a Deadly Brain Tumor in Children?

Solving Kids’ Cancer identified a novel trial using a cancer vaccine modeled after one used in adults for a deadly brain tumor called glioblastoma. As part of this trial, the…

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Will Targeted Radiation Stop a Deadly Brain Tumor?

Solving Kids’ Cancer supported this project because better methods to deliver treatments to the brain stem are urgently needed. In this research study, children with DIPG are treated with an…

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Sarcomas

Can T-Cell Immunotherapy Work in Osteosarcoma and Neuroblastoma?

This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and…

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Can We Train a Child’s Immune Cells to Recognize and Kill Cancer Cells?

Solving Kids’ Cancer supported this vaccine clinical trial that uses the cancer drug decitabine to help the immune cells better recognize and kill the cancer cells. Project Title: Combining Decitabine…

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By Engineering a Herpes Virus, Can We Target Tumor Cells?

HSV1716 (Seprehvir) is a “first in class” engineered oncolytic virus derived from the herpes simplex virus, and is designed to target and destroy cancer cells. Solving Kids’ Cancer brought this…

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Vinblastine and Sirolimus in Patients With Recurrent or Refractory Solid Tumors Including CNS Tumors

Solving Kids’ Cancer initiated a research project to screen thousands of drugs that were not used for cancer against neuroblastoma tumor-initiating stem cells. These cells are a special subset of…

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Can a Transplant Using a Parent’s Stem Cells Followed by a Parent’s NK Cells Help Fight Cancer in a Child?

Haploidentical transplant, which uses donor bone marrow from a half-matched parent or sibling, has been successful in curing some cancers, including leukemia.  Solving Kids’ Cancer supported this clinical trial based…

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Will a Modified Small Pox Virus Kill Cancer Cells?

Solving Kids’ Cancer initiated and funded the first trial in children using JX-594, a virus strain derived from the same vaccine used to eradicate small pox, for children with solid…

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